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Plasma losartan concentrations are twice as high in hypertensive women as hypertensive men, but plasma concentrations of active metabolite are similar.
Optimal targets for blood pressure control in chronic kidney disease.
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Take Losartan potassium tablets exactly as prescribed by your doctor.
When pregnancy is detected, discontinue losartan potassium tablets as soon as possible.
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Following an intravenous dose, 45% is recovered in the urine and 50% in the feces.
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Application of Direct Renin Inhibition to Chronic Kidney Disease.
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Lipoxygenase Inhibition on Microalbuminuria in Type-1 and Type-2 Diabetes Is Associated with Changes of Glomerular Angiotensin II Type 1 Receptor Related to Insulin Resistance.
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The information contained in the Truven Health Analytics products is intended as an educational aid only.
If you experience any of the following serious side effects, stop taking Cozaar and contact your doctor immediately or seek emergency medical treatment.
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ACE inhibitors) are often used to reduce the formation of the more potent angiotensin II.
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The present trial shows that treatment with 300 mg of aliskiren daily reduces albuminuria in patients with hypertension, type 2 diabetes, and proteinuria who are receiving the recommended maximal renoprotective treatment with losartan and optimal antihypertensive therapy.
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Each dose should be taken with a full glass (8 ounces) of water, and either with or without food.
Three overnight urine specimens were obtained on 3 sequential nights 2 weeks before randomization (baseline) and 12 and 24 weeks after randomization.
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It puts an enormous amount of pressure on the cardiovascular system, and often leads to strokes, heart attacks, and other forms of heart disease when left unchecked.
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Because the protocol identified one primary comparison, the reported P values were not corrected for multiple comparisons.
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In Phase II and III trials of decompensated heart failure, continuous infusions of brain natriuretic peptide (BNP) caused dose-related decreases in pulmonary capillary wedge pressure and systemic vascular resistance.
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ABPM profiles of hourly DBP means measured at baseline and at the end of the active treatment period for both drugs.
The usual dose of Losartan for most adult patients is one 50mg tablet once a day to control your blood pressure over the 24-hour period.
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Clinical Practice Guidelines for the Management of Hypertension in the Community.
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Five patients (three in group 2 and two in group 4) withdrew during uptitration because of adverse events.
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Hypertension in patients with chronic kidney disease.
Losartan is in a class of medications called angiotensin II receptor antagonists.
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The effects of angiotensin-II receptor blockers on podocyte damage and glomerular apoptosis in a rat model of experimental streptozotocin-induced diabetic nephropathy.
Furthermore, the incidence of end-stage renal disease in patients with type 2 diabetes is rising sharply in many regions of the world and is expected to double by 2010.
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Providing the isotopically-labelled intravenous dose is sufficiently low so as not to perturb the systemic drug concentrations achieved from the absorbed oral dose, then the intravenous and oral pharmacokinetics can be deconvoluted by virtue of their different isotopic constitution and thereby determine the oral and intravenous pharmacokinetics from the same dose administration.
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It may also be used for other conditions as determined by your doctor.
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Telmisartan increases localization of glucose transporter 4 to the plasma membrane and increases glucose uptake via peroxisome proliferator-activated receptor γ in 3T3-L1 adipocytes.
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